drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR-T)
drug_description
Autologous gene-modified T lymphocytes expressing a CAR targeting CSPG4, incorporating an inducible caspase-9 safety switch; mediates HLA-independent killing of CSPG4-positive tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Cell- and Tissue-Based Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells genetically engineered to express a CAR targeting CSPG4; upon antigen engagement they activate and kill CSPG4-positive tumor cells in an HLA-independent manner via cytotoxic effector pathways. The construct includes an inducible caspase-9 safety switch enabling on-demand ablation of the CAR-T cells to manage severe toxicity.
drug_name
iC9.CAR-CSPG4 autologous CAR-T cells
nct_id_drug_ref
NCT06096038