drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate (intravenous)
drug_description
A TM4SF1-directed antibody–drug conjugate (ADC). A monoclonal antibody binds TM4SF1 on tumor cells and tumor-associated endothelial cells, is internalized, and releases a cytotoxic payload to induce cell death, enabling both direct tumor killing and vascular targeting/anti-angiogenic effects.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
TM4SF1-targeted monoclonal antibody linked to a cytotoxic payload; upon binding TM4SF1 on tumor cells and tumor-associated endothelial cells, the ADC is internalized and releases the payload to induce cell death, enabling direct tumor killing and vascular targeting/anti-angiogenic effects.
drug_name
AGX101
nct_id_drug_ref
NCT06440005