drug_type
RELEVANT_DRUG
intervention_type
Adoptive cell therapy
drug_description
Adoptive cell therapy consisting of a single IV infusion of ex vivo expanded autologous tumor-reactive T cells to augment anti-tumor immunity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Adoptive Immunotherapy
drug_category
TCR SELECTED T CELLS
drug_class
Unedited cells
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are isolated and expanded ex vivo based on functional reactivity to tumor antigens. After infusion, these TCR-mediated tumor‑specific CD4+/CD8+ T cells recognize peptide–MHC complexes on tumor cells, release cytotoxic granules and inflammatory cytokines, and augment anti‑tumor immunity.
drug_name
TTRNA-xALT (autologous tumor-reactive T cells)
nct_id_drug_ref
NCT06254326