drug_type
RELEVANT_DRUG
intervention_type
Therapeutic DNA plasmid vaccine
drug_description
Therapeutic DNA plasmid vaccine targeting HPV-16/18 for cervical HSIL; delivered intramuscularly with electroporation to enhance plasmid uptake and antigen expression, inducing HPV-specific CD8+ and CD4+ T-cell responses to clear infected dysplastic cervical epithelial cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
DNA Vaccines
drug_category
GENE THERAPY
drug_class
Vaccine
drug_delivery_route
Intramuscular
drug_mechanism_of_action
Plasmid DNA encoding HPV-16/18 antigens is delivered intramuscularly with electroporation to enhance cellular uptake and expression; the expressed antigens are presented via MHC I/II to induce HPV-specific CD8+ cytotoxic and CD4+ helper T-cell responses that eliminate HPV-16/18–infected dysplastic cervical epithelial cells.
drug_name
NWRD08
nct_id_drug_ref
NCT06276101