drug_type
RELEVANT_DRUG
intervention_type
Antibody–drug conjugate (HER2-directed)
drug_description
HER2-targeted biparatopic antibody–drug conjugate (ADC) that binds two non-overlapping HER2 extracellular epitopes (ECD2 and ECD4), enhances receptor internalization and downregulates surface HER2 to provide dual HER2 signaling blockade while delivering a cytotoxic payload.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
TQB2102 is a HER2-directed biparatopic antibody-drug conjugate that binds two non-overlapping HER2 extracellular epitopes (ECD2 and ECD4), drives receptor internalization and surface HER2 downregulation to block HER2 signaling, and releases an intracellular cytotoxic payload to kill HER2-expressing tumor cells.
drug_name
TQB2102 for injection
nct_id_drug_ref
NCT06767800