drug_type
RELEVANT_DRUG
intervention_type
Drug - antibody-drug conjugate (ADC)
drug_description
An anti-c-Met antibody–drug conjugate (ADC) that binds MET (c-Met) on tumor cells, is internalized, and releases a topoisomerase I inhibitor payload causing DNA damage and cell death; disrupts MET-driven signaling.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Monoclonal antibody targets MET (c-Met) on tumor cells; after binding and internalization, releases a topoisomerase I inhibitor payload that induces DNA damage and cell death while disrupting MET-driven signaling.
drug_name
Telisotuzumab adizutecan (ABBV-400)
nct_id_drug_ref
NCT06614192