drug_type
RELEVANT_DRUG
intervention_type
Small molecule
drug_description
Small-molecule dimerizer that activates an inducible caspase-9 safety switch to ablate the engineered cells if required.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Rimiducid
drug_category
SMALL MOLECULE DRUG
drug_class
Other treatment
drug_delivery_route
Intravenous
drug_mechanism_of_action
Rimiducid (AP1903) is a synthetic dimerizer that binds FKBP12-F36V domains on the inducible caspase-9 (iCasp9) safety switch in engineered cells, inducing caspase-9 dimerization and activation, triggering the apoptotic cascade and rapid ablation of the modified cells.
drug_name
Rimiducid (AP1903)
nct_id_drug_ref
NCT06066424