drug_type
RELEVANT_DRUG
intervention_type
antibody-drug conjugate
drug_description
HER2-targeted antibody-drug conjugate that delivers the microtubule toxin MMAE to tumor cells to induce apoptosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Disitamab Vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Disitamab vedotin is a HER2-targeted antibody–drug conjugate that binds HER2 on tumor cells, is internalized, and releases the cytotoxic payload MMAE via a cleavable linker. MMAE disrupts microtubules, causing G2/M arrest and apoptosis, with potential bystander killing due to membrane-permeable payload.
drug_name
Disitamab vedotin (RC48)
nct_id_drug_ref
NCT06540729