drug_type
RELEVANT_DRUG
intervention_type
Biological (mRNA cancer vaccine)
drug_description
A personalized mRNA cancer vaccine encoding patient-specific tumor neoantigens; the mRNA is taken up by host antigen-presenting cells, translated, and presented via HLA to prime and expand neoantigen-specific CD8+ and CD4+ T cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Cancer Vaccines
drug_category
mRNA VACCINE
drug_class
Vaccine
drug_delivery_route
Not Reported
drug_mechanism_of_action
Personalized mRNA encoding patient-specific tumor neoantigens is taken up by host antigen-presenting cells, translated into neoantigen peptides, processed and presented on HLA class I and II, thereby priming and expanding neoantigen-specific CD8+ cytotoxic and CD4+ helper T cells to drive antitumor immunity.
drug_name
mRNA-0217/S001 personalized neoantigen tumor vaccine
nct_id_drug_ref
NCT05916261