drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody (EGFR inhibitor)
drug_description
Chimeric anti-EGFR IgG1 monoclonal antibody used here to ablate EGFRt-tagged CAR T cells as a safety switch.
nci_thesaurus_concept_id
C1723
nci_thesaurus_preferred_term
Cetuximab
nci_thesaurus_definition
A recombinant, chimeric monoclonal antibody directed against the epidermal growth factor (EGFR) with antineoplastic activity. Cetuximab binds to the extracellular domain of the EGFR, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization may result in an inhibition in signal transduction and anti-proliferative effects. This agent may inhibit EGFR-dependent primary tumor growth and metastasis. EGFR is overexpressed on the cell surfaces of various solid tumors.
drug_mesh_term
Cetuximab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Chimeric IgG1 monoclonal antibody that binds the extracellular domain of EGFR, blocking ligand binding and receptor dimerization to inhibit downstream signaling and tumor cell proliferation; can elicit immune effector functions (e.g., ADCC). In this study, used to target the EGFRt safety tag to ablate EGFRt-tagged CAR T cells on demand.
drug_name
Cetuximab
nct_id_drug_ref
NCT06447987