drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
An anti-CD33 antibody–drug conjugate that binds CD33 on AML blasts and, after internalization, releases the cytotoxic payload calicheamicin to induce DNA double-strand breaks and apoptosis; immune effector functions are minor relative to payload delivery.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Gemtuzumab Ozogamicin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized anti-CD33 antibody–drug conjugate that binds CD33 on AML blasts, is internalized, and intracellularly releases the cytotoxic payload calicheamicin, causing DNA double-strand breaks and apoptotic cell death; immune effector functions are minimal relative to payload-mediated cytotoxicity.
drug_name
Gemtuzumab ozogamicin (Mylotarg)
nct_id_drug_ref
NCT05189639