drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Engineered protein cytotoxin that binds integrin αvβ3 and induces apoptosis in αvβ3-expressing cells to remodel the tumor microenvironment.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
CYTOTOXIC FUSION PROTEIN
drug_class
Cytotoxic protein
drug_delivery_route
Intravenous
drug_mechanism_of_action
Engineered protein cytotoxin that binds integrin αvβ3 and induces caspase-mediated apoptosis in αvβ3-expressing stromal, endothelial, and tumor cells, depleting these populations and remodeling the tumor microenvironment.
drug_name
ProAgio (ACT50)
nct_id_drug_ref
NCT06182072