drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
Autologous ex vivo dendritic cell-sensitized cytotoxic T lymphocytes with NK-like cytotoxic features, administered intraperitoneally to kill residual peritoneal tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
T-Lymphocytes, Cytotoxic
drug_category
TCR SELECTED T CELLS
drug_class
Unedited cells
drug_delivery_route
Intraperitoneal
drug_mechanism_of_action
Autologous cytotoxic T lymphocytes expanded ex vivo by dendritic cell sensitization to enrich native TCR tumor specificity; upon intraperitoneal infusion, they kill residual peritoneal tumor cells via antigen-specific TCR recognition and perforin/granzyme release, augmented by NK-like cytotoxic pathways (e.g., NKG2D-mediated killing).
drug_name
Autologous Natural Killer Cell-like Cytotoxic T Lymphocytes (nCTLs)
nct_id_drug_ref
NCT03735589