drug_type
RELEVANT_DRUG
intervention_type
cellular therapy (CAR T cells)
drug_description
Autologous chimeric antigen receptor T-cell therapy engineered to target BCMA on malignant plasma cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are genetically engineered to express a chimeric antigen receptor that recognizes BCMA on malignant plasma cells, triggering MHC-independent T-cell activation, proliferation, cytokine release, and perforin/granzyme-mediated cytotoxic killing of the target cells.
drug_name
BCMA-directed CAR T-cell therapy
nct_id_drug_ref
NCT05801939