drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
Allogeneic, off-the-shelf anti-CD70 UCAR-T cell therapy (genetically engineered CAR T cells) that targets CD70 on tumor cells to trigger T-cell activation, cytotoxic killing, and cytokine release.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic, off-the-shelf CAR T cells engineered with an anti-CD70 chimeric antigen receptor bind CD70 on tumor cells and activate CAR signaling, leading to T-cell activation, cytokine release, and cytotoxic lysis of CD70-expressing tumor cells.
drug_name
CHT101
nct_id_drug_ref
NCT06383507