drug_type
RELEVANT_DRUG
intervention_type
mRNA cancer vaccine (personalized)
drug_description
Personalized mRNA cancer vaccine encoding patient-specific tumor neoantigens; taken up by antigen-presenting cells and presented on MHC I/II to prime CD8+ and CD4+ T-cell responses.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
mRNA VACCINE
drug_class
Vaccine
drug_delivery_route
Intramuscular
drug_mechanism_of_action
Personalized lipid‑nanoparticle mRNA vaccine encoding patient-specific tumor neoantigens. After uptake by antigen‑presenting cells, the mRNA is translated and neoantigen peptides are presented on MHC I/II, priming and expanding tumor‑specific CD8+ cytotoxic and CD4+ helper T cells to drive antitumor immunity.
drug_name
Intismeran autogene (V940/mRNA-4157)
nct_id_drug_ref
NCT06623422