drug_type
RELEVANT_DRUG
intervention_type
Biological (monoclonal antibody)
drug_description
A human IgG1 monoclonal antibody targeting OX40 (CD134) on activated T cells; blocks OX40–OX40L costimulatory signaling and can deplete OX40+ T cells via ADCC, reducing T‑cell survival and pathogenic type 2 inflammation.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Human IgG1 monoclonal antibody that binds OX40 (CD134) on activated T cells, blocks OX40-OX40L costimulatory signaling to suppress T-cell survival/activation and type 2 cytokine responses, and can deplete OX40+ T cells via ADCC.
drug_name
Rocatinlimab (AMG 451)
nct_id_drug_ref
NCT06438263