drug_type
RELEVANT_DRUG
intervention_type
Small molecule antiviral prodrug
drug_description
Small-molecule antiviral prodrug of ganciclovir; in this study it is phosphorylated by HSV-eTK expressed from GEN2 to induce selective tumor cell death.
nci_thesaurus_concept_id
C2629
nci_thesaurus_preferred_term
Valganciclovir
nci_thesaurus_definition
A synthetic prodrug of ganciclovir, a nucleoside analogue of 2-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, viral DNA synthesis, and viral replication. (NCI04)
drug_mesh_term
Valganciclovir
drug_category
SMALL MOLECULE DRUG
drug_class
Inhibitor
drug_delivery_route
Oral
drug_mechanism_of_action
Valganciclovir is a prodrug of ganciclovir (a deoxyguanosine analogue). After phosphorylation by HSV-enhanced thymidine kinase (expressed by the GEN2 vector) and subsequent cellular kinases, the active triphosphate is incorporated into DNA, inhibiting DNA polymerase and causing DNA chain termination, leading to selective death of transduced tumor cells.
drug_name
Valganciclovir
nct_id_drug_ref
NCT06391918