drug_type
RELEVANT_DRUG
intervention_type
Biologic drug (monoclonal antibody, immunotherapy)
drug_description
Anti-CD47 monoclonal antibody immunotherapy that blocks the CD47–SIRPα "don’t‑eat‑me" signal to promote macrophage-mediated phagocytosis and innate antitumor immunity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
magrolimab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-CD47 monoclonal antibody that blocks the CD47–SIRPα inhibitory ('don’t‑eat‑me') signal on tumor cells, enabling macrophage-mediated phagocytosis (ADCP) and enhancing innate antitumor immunity, with potential downstream priming of adaptive responses.
drug_name
Magrolimab (Hu5F9-G4)
nct_id_drug_ref
NCT05807126