drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
A HER2-targeted antibody–drug conjugate (IgG1 anti-HER2 linked to MMAE) that binds HER2 on tumor cells, is internalized, releases MMAE to inhibit microtubules causing mitotic arrest and apoptosis, and may also trigger ADCC.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Disitamab Vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-targeted IgG1 antibody–drug conjugate that binds HER2 on tumor cells, is internalized, and via a cleavable linker releases MMAE, a microtubule inhibitor, causing mitotic arrest and apoptosis; the IgG1 backbone may also mediate Fc-dependent ADCC.
drug_name
Disitamab vedotin (RC48)
nct_id_drug_ref
NCT06660511