drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
Chimeric IgG1 monoclonal antibody against TNF-α that neutralizes soluble and transmembrane TNF-α, suppressing TNFR1/2→NF-κB signaling, macrophage activation, and Th1/Th17-driven granuloma maintenance.
nci_thesaurus_concept_id
C1789
nci_thesaurus_preferred_term
Infliximab
nci_thesaurus_definition
A recombinant chimeric, mouse-human monoclonal antibody directed against tumor necrosis factor alpha (TNF-alpha), a protein involved in inflammation, cell survival, and apoptosis. Infliximab may be pro- apoptotic or anti-apoptotic, depending on cell type. (NCI04)
drug_mesh_term
Infliximab
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Chimeric IgG1 monoclonal antibody that binds and neutralizes soluble and transmembrane TNF-alpha, preventing TNFR1/2 engagement and downstream NF-kB signaling, thereby reducing macrophage activation, Th1/Th17-mediated inflammation, and granuloma maintenance.
drug_name
Infliximab
nct_id_drug_ref
NCT05689879