drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
A biological monoclonal antibody targeting the KIT (CD117) receptor; blocks KIT/stem cell factor signaling to suppress and deplete mast cells, aiming to reduce mast cell–driven inflammation in eosinophilic esophagitis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibodies, Monoclonal
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Monoclonal antibody targeting KIT (CD117) that blocks stem cell factor (SCF)–KIT signaling, suppressing and depleting mast cells and thereby reducing mast cell–driven inflammation (e.g., in eosinophilic esophagitis).
drug_name
barzolvolimab (CDX-0159)
nct_id_drug_ref
NCT05774184