drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
Recombinant humanized anti-EGFR (HER1/ErbB1) IgG monoclonal antibody that binds the extracellular domain of EGFR to block ligand binding and receptor activation, inhibiting downstream RAS-RAF-MEK-ERK and PI3K-AKT signaling; may also mediate ADCC against EGFR-expressing tumor cells.
nci_thesaurus_concept_id
C163981
nci_thesaurus_definition
A glycoengineered humanized version of the monoclonal antibody of cetuximab, with potential antineoplastic activity. Upon intravenous administration, pimurutamab selectively targets and binds to the extracellular domain of the epidermal growth factor receptor (EGFR), thereby preventing the activation and subsequent dimerization of the receptor. This may prevent EGFR-mediated signaling and inhibit EGFR-dependent tumor cell proliferation. In addition, the glyco-optimization promotes antibody-dependent cell-mediated cytotoxicity (ADCC). EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of certain tumor types.
drug_mesh_term
HLX07
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized anti-EGFR IgG monoclonal antibody that binds the extracellular domain of EGFR (HER1), blocking ligand binding and receptor dimerization/activation to inhibit downstream RAS-RAF-MEK-ERK and PI3K-AKT signaling and tumor cell proliferation; Fc-mediated effector function may also induce ADCC against EGFR-expressing cells.
drug_name
HLX07
nct_id_drug_ref
NCT05360368