drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
A bispecific antibody–drug conjugate (ADC) composed of fully human common light-chain antibodies that simultaneously target c-MET (HGF receptor) and EGFR on tumor cells. Dual binding promotes internalization and intracellular release of a cytotoxic payload, killing c-MET/EGFR–expressing cells and concurrently inhibiting MET and EGFR signaling. Administered intravenously as monotherapy every 3 weeks in Phase 1 dose escalation/expansion.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Bispecific antibody–drug conjugate that binds c-MET and EGFR on tumor cells, triggering internalization and lysosomal release of a cytotoxic payload to kill target-expressing cells, while concurrently inhibiting MET and EGFR signaling pathways.
drug_name
DM005
nct_id_drug_ref
NCT06515990