drug_type
RELEVANT_DRUG
intervention_type
Cellular gene therapy (CAR-T)
drug_description
Autologous CAR-T cells engineered to target HER2 (ERBB2), designed for MHC-independent recognition and killing of HER2-expressing tumors with activation via CD3ΞΆ and costimulatory signaling domains.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells engineered to express a HER2-specific chimeric antigen receptor. Binding to HER2 triggers CD3zeta and costimulatory signaling, activating the T cells to proliferate, release cytokines, and kill HER2-expressing tumor cells via perforin/granzyme in an MHC-independent manner.
drug_name
HER2-directed CAR-T cells
nct_id_drug_ref
NCT06515626