drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy
drug_description
Autologous dual-target CAR-T cell therapy directed against BCMA (TNFRSF17) and CD19 for relapsed/refractory multiple myeloma; engineered T cells recognize BCMA/CD19 to activate cytotoxic killing of malignant plasma/B-lineage cells.
nci_thesaurus_concept_id
C175471
nci_thesaurus_preferred_term
Autologous Bispecific BCMA/CD19-targeted CAR-T Cells GC012F
nci_thesaurus_definition
A preparation of autologous T-lymphocytes engineered to express two separate chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) BCMA and CD19 and fused to as of yet not fully elucidated co-stimulatory domains, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous bispecific BCMA/CD19-targeted CAR-T cells GC012F specifically and simultaneously target and bind to tumor cells expressing BCMA and/or CD19. This induces selective toxicity in tumor cells that express BCMA and/or CD19. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies. The processing platform used, FasT CAR-T, shortens the manufacturing time to produce the CAR-T cells within 24 hours.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells are genetically engineered to express dual chimeric antigen receptors targeting BCMA (TNFRSF17) and CD19. Upon binding to BCMA- or CD19-expressing malignant plasma/B-lineage cells, the CAR-T cells activate, release cytokines, and mediate perforin/granzyme-dependent cytotoxic killing; dual targeting aims to reduce antigen escape and deepen anti-myeloma responses.
drug_name
GC012F
nct_id_drug_ref
NCT06235229