drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T)
drug_description
Autologous CD19-targeted Nex-T CAR T-cell therapy; engineered T cells recognize CD19 and deplete pathogenic B-cell subsets to reduce autoantibodies and reset immune tolerance.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells engineered to express a CD19-specific chimeric antigen receptor; after infusion they recognize and kill CD19-positive B-cell subsets (naive/memory B cells and plasmablasts), depleting pathogenic B cells to reduce autoantibody production and help reset immune tolerance.
drug_name
CC-97540 (BMS-986353)
nct_id_drug_ref
NCT05869955