drug_type
RELEVANT_DRUG
intervention_type
Drug
drug_description
An antibody–drug conjugate (human IgG1) targeting B7-H3 (CD276); upon binding and internalization, a cleavable linker releases a duocarmycin DNA-alkylating payload that induces minor-groove alkylation and tumor cell death; the IgG1 backbone may contribute Fc-mediated cytotoxicity and a bystander effect.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
Human IgG1 antibody–drug conjugate targeting B7-H3 (CD276). Upon antigen binding and internalization, a cleavable linker releases a duocarmycin payload that alkylates DNA in the minor groove, inducing tumor cell death; the IgG1 Fc may contribute ADCC/CDC and a bystander effect.
drug_name
Vobramitamab duocarmazine (MGC018)
nct_id_drug_ref
NCT05551117