drug_type
RELEVANT_DRUG
intervention_type
Cellular immunotherapy (gene-modified T cells)
drug_description
Allogeneic, gene-modified T cells engineered to express a chimeric NK receptor that redirects them to tumor-associated ligands and activates T-cell cytotoxic signaling (via ITAM/CD3zeta), promoting perforin/granzyme-mediated killing and cytokine release against B7-H3-expressing neuroblastoma.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Immunotherapy, Adoptive
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic, gene-modified T cells engineered with a chimeric NK receptor that binds tumor-associated ligands on B7-H3–expressing neuroblastoma and signals through ITAM/CD3ζ to activate T-cell effector functions, driving perforin/granzyme-mediated cytolysis and cytokine release.
drug_name
Chimeric Natural Killer Receptor-Universal T cells (CNK-UT)
nct_id_drug_ref
NCT06751134