drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (gene-modified autologous T cells)
drug_description
Autologous T cells genetically engineered to express a chimeric antigen receptor targeting GD2; infused intravenously to kill GD2-positive diffuse midline glioma cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells engineered to express a chimeric antigen receptor specific for GD2 bind GD2 on tumor cells and, upon CAR signaling, activate T-cell effector functions (granzyme/perforin-mediated cytotoxicity and cytokine release) to kill GD2-positive diffuse midline glioma cells.
drug_name
GD2 CAR T cells
nct_id_drug_ref
NCT05544526