drug_type
RELEVANT_DRUG
intervention_type
Drug (antibody–drug conjugate)
drug_description
A CDH6-targeting antibody–drug conjugate (DAR-8) administered IV every 21 days; binds Cadherin-6 on tumor cells, is internalized, and releases a cytotoxic payload to kill CDH6-expressing cancer cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antibody-Drug Conjugates
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HS-20124 is a CDH6-targeting monoclonal antibody–drug conjugate that binds Cadherin-6 on tumor cells, is internalized, and releases a cytotoxic payload intracellularly, leading to targeted killing of CDH6-expressing cancer cells.
drug_name
HS-20124
nct_id_drug_ref
NCT06763159