drug_type
RELEVANT_DRUG
intervention_type
Biological (cellular therapy)
drug_description
Off-the-shelf allogeneic CAR T-cell therapy engineered to express a CAR targeting CD38 to promote T-cell mediated cytotoxicity against AML cells expressing CD38.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic off-the-shelf T cells engineered with a CD38-specific chimeric antigen receptor bind CD38 on AML cells, triggering CAR signaling and T-cell activation to mediate cytotoxic killing (perforin/granzyme) of CD38-expressing leukemic cells.
drug_name
CD38-specific universal CAR T cells
nct_id_drug_ref
NCT05995041