drug_type
RELEVANT_DRUG
intervention_type
Biological (cellular therapy)
drug_description
Off-the-shelf allogeneic CAR T-cell therapy engineered to express a CAR targeting CD123 (IL-3Rα) to drive antigen-specific T-cell killing of AML blasts and leukemic stem cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Allogeneic (off-the-shelf) T cells engineered to express a chimeric antigen receptor targeting CD123 (IL-3Rα). CAR engagement of CD123 on AML blasts and leukemic stem cells triggers T-cell activation, proliferation, cytokine release, and perforin/granzyme-mediated cytotoxic killing of target cells.
drug_name
CD123-specific universal CAR T cells
nct_id_drug_ref
NCT05995041