drug_type
RELEVANT_DRUG
intervention_type
mRNA vaccine
drug_description
An intramuscular mRNA nanoparticle vaccine encoding mutant KRAS neoantigens; taken up by antigen-presenting cells and presented on MHC I/II to prime KRAS-specific CD8+ and CD4+ T cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
mRNA VACCINE
drug_class
Vaccine
drug_delivery_route
Intramuscular
drug_mechanism_of_action
Intramuscular mRNA nanoparticle vaccine encoding mutant KRAS neoantigens; taken up by antigen-presenting cells, translated, and presented on MHC I and II to prime and expand KRAS-specific CD8+ cytotoxic and CD4+ helper T cells, promoting immune-mediated killing of KRAS-mutant tumor cells.
drug_name
ABO2102
nct_id_drug_ref
NCT06577532