drug_type
RELEVANT_DRUG
intervention_type
mRNA vaccine (biologic)
drug_description
An HPV-16–targeted therapeutic mRNA vaccine that delivers mRNA encoding HPV-16 antigens; after intramuscular injection, host cells translate the mRNA and present antigens on MHC I/II to activate antigen-presenting cells and prime HPV-16–specific CD8+ and CD4+ T-cell responses to eliminate HPV-16–positive lesions and tumors.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Papillomavirus Vaccines
drug_category
mRNA VACCINE
drug_class
Vaccine
drug_delivery_route
Intramuscular
drug_mechanism_of_action
Delivers mRNA encoding HPV-16 antigens to host cells; translated antigens are presented on MHC I/II, activating antigen-presenting cells and priming HPV-16–specific CD8+ cytotoxic and CD4+ helper T-cell responses to eliminate HPV-16–positive lesions and tumors.
drug_name
NWRD09
nct_id_drug_ref
NCT06741150