drug_type
RELEVANT_DRUG
intervention_type
Biologic
drug_description
Polyclonal anti-T-cell antibody used in conditioning for T-cell depletion prior to HSCT.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antithymocyte Globulin
drug_category
CYTOTOXIC ANTIBODY
drug_class
Cytotoxic protein
drug_delivery_route
Intravenous
drug_mechanism_of_action
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens (e.g., CD2, CD3, CD4, CD8, HLA-DR), depleting T lymphocytes via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and apoptosis, resulting in profound T-cell immunosuppression and reduction of alloreactivity before HSCT.
drug_name
Antithymocyte Globulin (Thymoglobulin; ATG)
nct_id_drug_ref
NCT06646497