drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
A human afucosylated IgG1 monoclonal antibody (HZN-7734) that binds ILT7 (LILRA4) on plasmacytoid dendritic cells, depleting them via enhanced ADCC to reduce type I interferon signaling; administered subcutaneously.
nci_thesaurus_concept_id
C174660
drug_mesh_term
Antibodies, Monoclonal
drug_category
CYTOTOXIC ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Subcutaneous
drug_mechanism_of_action
Afucosylated IgG1 monoclonal antibody that binds ILT7 (LILRA4) on plasmacytoid dendritic cells, enhancing FcγRIIIa-mediated ADCC to deplete pDCs and thereby reduce type I interferon production and downstream inflammatory signaling.
drug_name
Daxdilimab
nct_id_drug_ref
NCT05540665