drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody (anti-TIGIT immune checkpoint inhibitor)
drug_description
Humanized IgG1 monoclonal antibody targeting TIGIT to block TIGIT–CD155 signaling and enhance anti-tumor immunity; Fcγ-engaging checkpoint inhibitor.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Humanized IgG1 monoclonal antibody against TIGIT that blocks TIGIT–CD155 (and CD112) interactions, relieving inhibitory signaling on T and NK cells to restore anti-tumor activity; the Fcγ-engaging IgG1 can recruit effector functions (e.g., ADCC/ADCP) against TIGIT-expressing cells.
drug_name
Ociperlimab (BGB-A1217)
nct_id_drug_ref
NCT05791097