drug_type
RELEVANT_DRUG
intervention_type
Monoclonal antibody (anti-CD3)
drug_description
Anti-CD3 monoclonal antibody used to activate T cells ex vivo and to coat cells, engaging CD3/TCR signaling to redirect T-cell cytotoxicity.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Muromonab-CD3
drug_category
SIGNALING PROTEIN
drug_class
General immune activator
drug_delivery_route
Intravenous
drug_mechanism_of_action
Anti-CD3 monoclonal antibody that binds the CD3 complex on T cells to trigger TCR signaling and activation; when used to coat/arm T cells (often alongside a tumor-targeting antibody), it engages CD3 to form an immune synapse and redirects T-cell cytotoxicity toward antigen-positive targets.
drug_name
Muromonab-CD3 (OKT3)
nct_id_drug_ref
NCT04864522