drug_type
RELEVANT_DRUG
intervention_type
Antibody-drug conjugate
drug_description
HER2-directed antibody–drug conjugate: a humanized anti‑HER2 IgG1 linked to monomethyl auristatin E (MMAE). Binds HER2 on tumor cells, internalizes, and releases MMAE to disrupt microtubules, causing mitotic arrest/apoptosis; may also mediate ADCC and bystander killing.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-targeted antibody-drug conjugate: a humanized anti-HER2 IgG1 linked to the microtubule toxin MMAE. After binding HER2 and internalization, it releases MMAE to inhibit microtubule polymerization, causing mitotic arrest and apoptosis; may also mediate ADCC and bystander killing.
drug_name
Disitamab vedotin (RC48-ADC)
nct_id_drug_ref
NCT05745740