drug_type
RELEVANT_DRUG
intervention_type
Biological (mRNA cancer vaccine)
drug_description
Patient-specific mRNA vaccine encoding tumor neoantigens; after uptake by antigen-presenting cells (especially dendritic cells), translated antigens are presented on MHC I/II to prime and expand tumor-specific CD8+ cytotoxic and CD4+ helper T cells, broadening the TCR repertoire.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
RNA Vaccines
drug_category
mRNA VACCINE
drug_class
Vaccine
drug_delivery_route
Not specified
drug_mechanism_of_action
Personalized mRNA encoding tumor neoantigens is taken up by antigen-presenting cells (especially dendritic cells), translated into proteins, and processed for MHC I/II presentation, priming and expanding tumor-specific CD8+ cytotoxic and CD4+ helper T cells to broaden and strengthen anti-tumor immunity.
drug_name
Neoantigen mRNA Personalised Cancer vaccine
nct_id_drug_ref
NCT05949775