drug_type
RELEVANT_DRUG
intervention_type
Biological (cellular vaccine)
drug_description
Autologous dendritic cell vaccine pulsed with folate receptor alpha peptides, administered intradermally to prime and expand FRα-specific CD8+ and CD4+ T cells, enhance Th1/Th17 responses and anti-FRα IgG, promoting killing of FRα-positive ovarian tumor cells.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Dendritic Cell Vaccine
drug_category
DC VACCINE
drug_class
Vaccine
drug_delivery_route
Intradermal
drug_mechanism_of_action
Autologous dendritic cells pulsed with folate receptor alpha peptides present FRα epitopes on MHC I/II to prime and expand FRα-specific CD8+ cytotoxic T cells and CD4+ Th1/Th17 responses, also inducing anti-FRα IgG, leading to immune-mediated killing of FRα-positive ovarian tumor cells.
drug_name
Multi-epitope Folate Receptor Alpha-loaded Dendritic Cell Vaccine (FRαDC)
nct_id_drug_ref
NCT05920798