drug_type
RELEVANT_DRUG
intervention_type
Biologic (monoclonal antibody, anti-CD47)
drug_description
Anti-CD47 monoclonal antibody that blocks the CD47–SIRPalpha 'don't eat me' signal to enhance macrophage phagocytosis and antigen presentation.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
INHIBITORY ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
AK117 is an anti-CD47 monoclonal antibody that blocks the CD47–SIRPα immune checkpoint (“don’t eat me” signal), thereby enhancing macrophage-mediated tumor cell phagocytosis and improving antigen presentation to stimulate antitumor immune responses.
drug_name
AK117
nct_id_drug_ref
NCT05960955