drug_type
RELEVANT_DRUG
intervention_type
Cellular therapy (CAR T cells)
drug_description
Autologous T cells engineered to express a chimeric antigen receptor targeting GD2 with additional modules to resist tumor immunosuppression and enhance function/persistence for neuroblastoma.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Chimeric Antigen Receptor T-Cell Therapy
drug_category
CAR T
drug_class
Cellular Therapy
drug_delivery_route
Intravenous
drug_mechanism_of_action
Autologous T cells engineered to express a GD2‑specific chimeric antigen receptor. CAR engagement of GD2 on tumor cells activates T‑cell signaling to mediate targeted cytotoxicity; additional modules promote resistance to tumor immunosuppression and improve T‑cell function and persistence.
drug_name
GD2 CAR T cells
nct_id_drug_ref
NCT05990751