drug_type
RELEVANT_DRUG
intervention_type
antibody-drug conjugate
drug_description
A TROP2-targeting antibody-drug conjugate with a topoisomerase I inhibitor payload; binds TROP2 on tumor cells, is internalized, and releases the payload to induce DNA damage (with potential bystander effect).
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
TROP2-directed monoclonal antibody linked to a topoisomerase I inhibitor payload; upon binding TROP2 on tumor cells the ADC is internalized and releases the payload, inhibiting topoisomerase I to induce DNA damage and tumor cell death, with potential bystander effect.
drug_name
Sacituzumab tirumotecan (MK-2870)
nct_id_drug_ref
NCT06393374