drug_type
RELEVANT_DRUG
intervention_type
polyclonal antibody (immunoglobulin)
drug_description
A polyclonal immunoglobulin preparation that depletes T cells via complement-mediated lysis and apoptosis and exerts immune-modulatory effects; used peri-transplant to prevent graft-versus-host disease.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antithymocyte Globulin
drug_category
CYTOTOXIC ANTIBODY
drug_class
Inhibitor
drug_delivery_route
Intravenous
drug_mechanism_of_action
Polyclonal anti-thymocyte immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-mediated lysis, apoptosis, and Fc-dependent cytotoxicity, with additional immunomodulatory effects; used peri-transplant to suppress alloreactive T cells and prevent GVHD.
drug_name
Anti-thymocyte globulin (ATG)
nct_id_drug_ref
NCT06334367