drug_type
RELEVANT_DRUG
intervention_type
Biological
drug_description
Polyclonal anti-T-cell antibody used for T-cell depletion to reduce rejection and GVHD.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Antithymocyte Globulin
drug_category
CYTOTOXIC ANTIBODY
drug_class
Cytotoxic protein
drug_delivery_route
Intravenous
drug_mechanism_of_action
Polyclonal anti-T-cell immunoglobulin that binds multiple T-cell surface antigens and depletes T cells via complement-dependent cytotoxicity and Fc-mediated effector functions (e.g., ADCC and phagocytosis), resulting in profound T-cell immunosuppression to reduce rejection and GVHD.
drug_name
Anti-thymocyte globulin (ATG)
nct_id_drug_ref
NCT05508009