drug_type
RELEVANT_DRUG
intervention_type
monoclonal antibody
drug_description
An afucosylated humanized IgG1 monoclonal antibody targeting BCMA (TNFRSF17) on malignant plasma cells; mediates Fcγ receptor–dependent ADCC and ADCP and may induce apoptosis.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_category
CYTOTOXIC ANTIBODY
drug_class
Other treatment
drug_delivery_route
Intravenous
drug_mechanism_of_action
Afucosylated humanized IgG1 antibody that binds BCMA on malignant plasma cells; enhanced Fcγ receptor engagement drives NK cell–mediated ADCC and macrophage-mediated ADCP, and may also induce direct apoptosis of target cells.
drug_name
Belantamab (GSK2857914)
nct_id_drug_ref
NCT05714839