drug_type
RELEVANT_DRUG
intervention_type
antibody-drug conjugate (targeted therapy)
drug_description
HER2-targeted antibody–drug conjugate delivering MMAE to HER2-positive tumor cells, causing microtubule disruption and apoptosis; may also mediate ADCC.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Disitamab Vedotin
drug_category
ANTIBODY DRUG CONJUGATE
drug_class
Conjugate
drug_delivery_route
Intravenous
drug_mechanism_of_action
HER2-targeted antibody–drug conjugate that binds HER2 on tumor cells and is internalized; a cleavable linker releases the MMAE payload intracellularly to inhibit tubulin polymerization, causing G2/M arrest and apoptosis; the antibody Fc may also mediate ADCC and enable a bystander effect.
drug_name
Disitamab vedotin (RC48)
nct_id_drug_ref
NCT06227325