drug_type
RELEVANT_DRUG
intervention_type
Vaccine
drug_description
Therapeutic synthetic long peptide vaccine for chronic hepatitis B that is taken up by dendritic cells and presented via MHC class I and II to cross-prime HBV-specific CD8+ cytotoxic T cells and CD4+ Th1 cells, aiming to restore antiviral T-cell responses and enable CTL-mediated killing of HBV-infected hepatocytes.
nci_thesaurus_definition
NCI thesaurus definition not available.
drug_mesh_term
Hepatitis B Vaccines
drug_category
PEPTIDE VACCINE
drug_class
Vaccine
drug_delivery_route
Not specified
drug_mechanism_of_action
Synthetic long peptides are taken up by dendritic cells and presented on MHC class I and II to cross-prime HBV-specific CD8+ cytotoxic T cells and CD4+ Th1 cells, restoring antiviral T-cell responses and enabling CTL-mediated killing of HBV-infected hepatocytes.
drug_name
ISA104
nct_id_drug_ref
NCT05841095